Article
Induction of the SOS response and mutations by reactive oxygen-generating compounds in various Escherichia coli mutants defective in the mutM, mutY or soxRS loci.
Mutagenesis - 1 May 1994
Kato T, Watanabe M, Ohta T
Abstract excerpt
Derivatives of E. coli WP2s (uvrA trpE) defective in 7,8-dihydro-8-oxoguanine (8-OG) DNA glycosylase activity (mutM), MutY glycosylase activity on an A:8-OG mispair (mutY), and/or an adaptive response to oxidative stress by superoxide (soxRS) were constructed to compare the mutability to various...
Topics
- Bacterial Proteins
- DNA Glycosylases
- DNA-Formamidopyrimidine Glycosylase
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Mutation
- N-Glycosyl Hydrolases
- Oxidative Stress
- Reactive Oxygen Species
- SOS Response, Genetics
- Transcription Factors