Article
Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad.
Alcoholism, clinical and experimental research - 1 Feb 2007
Ehlers Cindy L, Montane-Jaime Karelia, Moore Shelly, Shafe Samuel, Joseph Roma, Carr Lucinda G
Abstract excerpt
BACKGROUND: Two of the class I alcohol dehydrogenase (ADH) genes located on chromosome 4 (ADH1B and ADH1C) encode for multiple isozymes that differ in their kinetic properties. At the ADH1B locus, 3 polymorphisms are present (ADH1B(*)1, ADH1B(*)2, ADH1B(*)3). ADH1B(*)2 (found mostly in individuals of East Asian and Jewish descent) and ADH1B(*)3 (found mostly in individuals of African decent) alleles encode for a...
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