Article
Identification and expression of novel isoforms of human stromal cell-derived factor 1.
Gene - 7 Jun 2006
Yu Lan, Cecil Jeffrey, Peng Sheng-Bin, Schrementi James, Kovacevic Steven, Paul Donald, Su Eric Wen, Wang Jian
Abstract excerpt
Stromal Cell-derived factor 1 (SDF-1) is a CXC chemokine that binds to the CXCR4 receptor. Recent publication indicates that the SDF-1/CXCR4 signaling pathway plays a pivotal role during development and in many patho-physiological conditions including hematopoiesis, blood vessel formation, cancer metastasis, angiogenesis and HIV infection. Two human SDF-1 isoforms, SDF-1alpha and SDF-1beta, have been reported to...
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