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Article

Adjusting the estimated proportion of breast cancer cases associated with BRCA1 and BRCA2 mutations: public health implications.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2005

McClain Monica R, Palomaki Glenn E, Nathanson Katherine L, Haddow James E

Abstract excerpt

PURPOSE: Mutations in BRCA1 or BRCA2 genes increase breast cancer risk. Assuring reliability of information about these mutations is increasingly important to the health care community; mutation testing is becoming more widespread. We describe a methodology for assessing such information. METHODS: Our approach integrates four interdependent epidemiologic parameters: (1) the probability of developing breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15654225
DOI: 10.1097/01.gim.0000151155.36470.ff

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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