Article
Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2014
Gabai-Kapara Efrat, Lahad Amnon, Kaufman Bella, Friedman Eitan, Segev Shlomo, Renbaum Paul, Beeri Rachel, Gal Moran, Grinshpun-Cohen Julia, Djemal Karen, Mandell Jessica B, Lee Ming K, Beller Uziel, Catane Raphael, King Mary-Claire, Levy-Lahad Ephrat
Abstract excerpt
In the Ashkenazi Jewish (AJ) population of Israel, 11% of breast cancer and 40% of ovarian cancer are due to three inherited founder mutations in the cancer predisposition genes BRCA1 and BRCA2. For carriers of these mutations, risk-reducing salpingo-oophorectomy significantly reduces morbidity and mortality. Population screening for these mutations among AJ women may be justifiable if accurate estimates of...
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