Article
Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila.
Molecular and cellular biology - 1 Apr 2007
Song Xiaoyuan, Gjoneska Elizabeta, Ren Qinghu, Taverna Sean D, Allis C David, Gorovsky Martin A
Abstract excerpt
Phosphorylation of the C terminus SQ motif that defines H2A.X variants is required for efficient DNA double-strand break (DSB) repair in diverse organisms but has not been studied in ciliated protozoa. Tetrahymena H2A.X is one of two similarly expressed major H2As, thereby differing both from mammals, where H2A.X is a quantitatively minor component, and from Saccharomyces cerevisiae where it is the only type of...
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