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Article

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation.

Molecular and cellular biology - 1 Apr 2007

Song Lun, Li Jingxia, Ye Jianping, Yu Gang, Ding Jin, Zhang Dongyun, Ouyang Weiming, Dong Zigang, Kim Sung O, Huang Chuanshu

Abstract excerpt

Apoptosis is an important cellular response to UV radiation (UVR), but the corresponding mechanisms remain largely unknown. Here we report that the p85alpha regulatory subunit of phosphatidylinositol 3-kinase (PI-3K) exerted a proapoptotic role in response to UVR through the induction of tumor necrosis factor alpha (TNF-alpha) gene expression. This special effect of p85alpha was unrelated to the PI-3K-dependent...

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Identifiers

PMID: 17242187
DOI: 10.1128/MCB.00657-06
PMCID: PMC1899908

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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