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Article

UV-A-induced AP-1 activation requires the Raf/ERK pathway in human NCTC 2544 keratinocytes.

Experimental dermatology - 1 Jun 2001

Djavaheri-Mergny M, Dubertret L

Abstract excerpt

UV-A irradiation causes a dose-dependent activation of ERK in human NCTC 2544 keratinocytes. The specific inhibition of either ERK activity or Raf kinase activity impedes the activation of AP-1 DNA binding induced by UV-A. In addition, UV-A raises AP-1 promoter transcriptional activity, which is downregulated in NCTC 2544 cells expressing an inactive mutant of Raf-1. We found that singlet oxygen might be one of...

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Identifiers

PMID: 11380616
DOI: 10.1034/j.1600-0625.2001.010003204.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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