Article
Transcriptional regulation of the sil locus by the SilCR signalling peptide and its implications on group A streptococcus virulence
18 Jan 2007
Abstract excerpt
In the last two decades an increasing number of local outbreaks of invasive group A streptococcus (GAS) infections including necrotizing fasciitis (NF) have been reported. We identified the streptococcal invasion locus (sil) which is essential for virulence of the M14 strain JS95 isolated from an NF patient. This locus contains six genes: silA/B and silD/E encoding two-component system (TCS) and ABC transporter,...
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