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Article

A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues.

The EMBO journal - 4 Oct 2006

Hidalgo-Grass Carlos, Mishalian Inbal, Dan-Goor Mary, Belotserkovsky Ilia, Eran Yoni, Nizet Victor, Peled Amnon, Hanski Emanuel

Abstract excerpt

Group A Streptococcus (GAS) causes the life-threatening infection in humans known as necrotizing fasciitis (NF). Infected subcutaneous tissues from an NF patient and mice challenged with the same GAS strain possessed high bacterial loads but a striking paucity of infiltrating polymorphonuclear leukocytes (PMNs). Impaired PMN recruitment was attributed to degradation of the chemokine IL-8 by a GAS serine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16977314
DOI: 10.1038/sj.emboj.7601327
PMCID: PMC1589981

Genes

MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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