Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster.

doi:10.1038/ng1944

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Article

Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster.

Nature genetics - 1 Feb 2007

Passador-Gurgel Gisele, Hsieh Wen-Ping, Hunt Priscilla, Deighton Nigel, Gibson Greg

Abstract excerpt

Although most genetic association studies are performed with the intention of detecting nucleotide polymorphisms that are correlated with a complex trait, transcript abundance should also be expected to associate with diseases or phenotypes. We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine...

Topics

Animals
California
Drosophila melanogaster
Drug Resistance
Female
Genetic Linkage
Genetic Variation
Glutamate Decarboxylase
Isoenzymes
Longevity
Mice
Nicotine
North Carolina
Ornithine-Oxo-Acid Transaminase
Quantitative Trait Loci
gamma-Aminobutyric Acid

Source

Open in PubMed

Identifiers

PMID: 17237783
DOI: 10.1038/ng1944

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