Article
Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2007
Rutjens Erik, Mazza Stefania, Biassoni Roberto, Koopman Gerrit, Radic Luana, Fogli Manuela, Costa Paola, Mingari Maria Cristina, Moretta Lorenzo, Heeney Jonathan, De Maria Andrea
Abstract excerpt
HIV-1 infection in chimpanzees, the closest human relative, rarely leads to disease progression. NK cells contribute to the shaping of adaptive immune responses in humans and show perturbed phenotype and function during HIV-1 infection. In this study, we provide full phenotypic, molecular, and functional characterization for triggering molecules (NKp46, NKp30 NKp80, and NKG2D) on Pan troglodytes NK cells. We...
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