Article
Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions.
Blood - 2 Oct 2014
Goodier Martin R, White Matthew J, Darboe Alansana, Nielsen Carolyn M, Goncalves Adriana, Bottomley Christian, Moore Sophie E, Riley Eleanor M
Abstract excerpt
Natural killer (NK) cells differentiate and mature during the human life course; human cytomegalovirus (HCMV) infection is a known driver of this process. We have explored human NK cell phenotypic and functional maturation in a rural African (Gambian) population with a high prevalence of HCMV. The effect of age on the frequency, absolute number, phenotype, and functional capacity of NK cells was monitored in 191...
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