The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse.

doi:10.1101/gad.414807

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Article

The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse.

Genes & development - 15 Jan 2007

Bauer Hermann, Véron Nathalie, Willert Jürgen, Herrmann Bernhard G

Abstract excerpt

Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1-4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A...

Topics

Alleles
Animals
Crosses, Genetic
Female
Gene Targeting
Guanine Nucleotide Exchange Factors
Haplotypes
Male
Mice
Microtubule-Associated Proteins
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Signal Transduction

Sperm Motility

Spermatozoa

Testis

t-Complex Genome Region

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PMID: 17234881
DOI: 10.1101/gad.414807
PMCID: PMC1770897

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