Genotype-treatment interaction between amantadine and chlorpromazine in the mouse.

doi:10.1016/0742-8413(91)90249-s

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Article

Genotype-treatment interaction between amantadine and chlorpromazine in the mouse.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology - 1 Jan 1991

Messiha F S

Abstract excerpt

1. Repeated administration of amantadine prior to chlorpromazine to two different strains of mice altered both locomotor activity, concentrations of brain biogenic amines and selected major metabolites as a function of mouse strain. 2. Amantadine antagonized chlorpromazine effect on motility which was associated with increases in whole brain levels of homovanillic acid in the CDF-1 but not C57BL/6 mice. 3....

Topics

Amantadine
Animals
Biogenic Amines
Brain
Chlorpromazine
Dopamine
Drug Interactions
Genotype
Hydroxyindoleacetic Acid
Methoxyhydroxyphenylglycol
Methylation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Inbred Strains

Motor Activity

Normetanephrine

Serotonin

Time Factors

Source

Open in PubMed

Identifiers

PMID: 1723037
DOI: 10.1016/0742-8413(91)90249-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1723037-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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