[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan].

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Article

[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan].

Schweizerische medizinische Wochenschrift - 7 Feb 1998

Oestreicher M K, Desmeules J, Piguet V, Allaz A F, Dayer P

Abstract excerpt

Administration of NMDA antagonists leads to attenuation or disappearance of some symptoms of central sensitization, such as secondary hyperalgesia. However, the side effects of NMDA antagonists to a large extent counterbalance the expected benefits, thus preventing wide or prolonged use. Dextrome...

Topics

Adult
Analgesics, Opioid
Antitussive Agents
Dextromethorphan
Double-Blind Method
Female
Humans
Male
Metabolic Clearance Rate
N-Methylaspartate
Pain Threshold
Phenotype
Receptors, N-Methyl-D-Aspartate
Retrospective Studies
Social Environment

Source

Open in PubMed

Identifiers

PMID: 9540144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9540144-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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