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Article

[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan].

Schweizerische medizinische Wochenschrift - 7 Feb 1998

Oestreicher M K, Desmeules J, Piguet V, Allaz A F, Dayer P

Abstract excerpt

Administration of NMDA antagonists leads to attenuation or disappearance of some symptoms of central sensitization, such as secondary hyperalgesia. However, the side effects of NMDA antagonists to a large extent counterbalance the expected benefits, thus preventing wide or prolonged use. Dextromethorphan and its metabolite dextrophan, on the other hand, are established and safe drugs. Experimentally they both...

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PMID: 9540144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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