Article
Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.
Journal of biochemistry - 1 Sept 1991
Hayashi S, Watanabe J, Nakachi K, Kawajiri K
Abstract excerpt
Individuals with high genetic risk of lung cancer had previously been identified by MspI polymorphisms of the cytochrome P450IA1 gene. In the present study we analyzed the structures of individual P450IA1 genes by PCR direct sequencing of genomic DNA of each genotype raised by the MspI polymorphi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cytochrome P-450 Enzyme System
- DNA, Neoplasm
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Gene Library
- Genetic Linkage
- Heme
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length