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Article

Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts.

The Journal of cell biology - 15 Jan 2007

Pekovic Vanja, Harborth Jens, Broers Jos L V, Ramaekers Frans C S, van Engelen Baziel, Lammens Martin, von Zglinicki Thomas, Foisner Roland, Hutchison Chris, Markiewicz Ewa

Abstract excerpt

In human diploid fibroblasts (HDFs), expression of lamina-associated polypeptide 2 alpha (LAP2alpha) upon entry and exit from G(0) is tightly correlated with phosphorylation and subnuclear localization of retinoblastoma protein (Rb). Phosphoisoforms of Rb and LAP2alpha are down-regulated in G(0). Although RbS780 phosphoform and LAP2alpha are up-regulated upon reentry into G(1) and colocalize in the nucleoplasm,...

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Identifiers

PMID: 17227891
DOI: 10.1083/jcb.200606139
PMCID: PMC2063936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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