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Article

Nuclear Accumulation of β-Catenin in Cancer Stem Cell Radioresistance and Stemness in Human Colon Cancer

1 Dec 2019

Abstract excerpt

BACKGROUND/AIM: The aim of this study was to examine whether the Wnt/β-catenin signal activation is a cause of radioresistance in colon cancer by assessing the β-catenin localization and its correlation with cancer stem cells (CSCs). MATERIALS AND METHODS: The nuclear levels of β-catenin, the hallmark of Wnt activation, were analyzed in HCT116 and SW480 cells by immunohistochemistry, before and after irradiation....

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PMID: 31810923
DOI: 10.21873/anticanres.13873

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