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Cancer Stem Cells in Radiation Resistance

1 Oct 2007

Abstract excerpt

Highly tumorigenic subpopulations of several solid cancers share characteristics with somatic stem cells. We showed recently that cancer stem cells, or tumor-initiating cells, derived from human glioblastoma surgical specimens and xenografts display resistance to radiation due to increased activation of the DNA damage checkpoint. We additionally showed that these same tumor subpopulations promote tumor...

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PMID: 17908997
DOI: 10.1158/0008-5472.can-07-0895

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