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Article

Segregation analysis and variance components analysis of bone mineral density in healthy families.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 1995

Guéguen R, Jouanny P, Guillemin F, Kuntz C, Pourel J, Siest G

Abstract excerpt

Bone mineral density (BMD) was measured in 1992-93 in 129 nuclear families, including 258 parents and 183 children, and was analyzed for familial resemblance factors. BMD measurements were adjusted on weight and age. Segregation analysis rejected the monogenic hypothesis and exhibited a strong polygenic component. Variance components analysis was then used to estimate the parameters of a multivariate normal model...

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Identifiers

PMID: 8619384
DOI: 10.1002/jbmr.5650101223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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