Article
Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys(10) and His(106).
The Biochemical journal - 1 Jan 2009
Wang Xin-Yu, Zhang Zai-Rong, Perrett Sarah
Abstract excerpt
GSTs (glutathione transferases) are an important class of enzymes involved in cellular detoxification. GSTs are found in all classes of organisms and are implicated in resistance towards drugs, pesticides, herbicides and antibiotics. The activity, structure and folding, particularly of eukaryotic GSTs, have therefore been widely studied. The crystal structure of EGST (GST from Escherichia coli) was reported...
Topics
- Amino Acid Sequence
- Circular Dichroism
- Cysteine
- Escherichia coli
- Escherichia coli Proteins
- Glutathione
- Glutathione Transferase
- Histidine
- Molecular Sequence Data
- Mutation
- Protein Binding