Article
Adaptive regulatory substitutions affect multiple stages in the life cycle of the bacteriophage φX174.
BMC evolutionary biology - 18 Mar 2013
Brown Celeste J, Stancik Amber D, Roychoudhury Pavitra, Krone Stephen M
Abstract excerpt
BACKGROUND: Previously, we showed that adaptive substitutions in one of the three promoters of the bacteriophage φX174 improved fitness at high-temperature by decreasing transcript levels three- to four-fold. To understand how such an extreme change in gene expression might lead to an almost two-fold increase in fitness at the adaptive temperature, we focused on stages in the life cycle of the phage that occur...
Topics
- Bacteriophage phi X 174
- Escherichia coli
- Gene Expression Regulation, Viral
- Genetic Fitness
- Models, Biological
- Mutation
- Transcription, Genetic
- Virus Assembly