Adaptive regulatory substitutions affect multiple stages in the life cycle of the bacteriophage φX174.

Abstract excerpt

BACKGROUND: Previously, we showed that adaptive substitutions in one of the three promoters of the bacteriophage φX174 improved fitness at high-temperature by decreasing transcript levels three- to four-fold. To understand how such an extreme change in gene expression might lead to an almost two-fold increase in fitness at the adaptive temperature, we focused on stages in the life cycle of the phage that occur...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacteriophage phi X 174
• Share to Escherichia coli