Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2- α ]quinoline in colon cancer cells depending on their p53 status

Abstract excerpt

In the present article, we describe a mechanistic study of a novel derivative of N-amidino-substituted benzimidazo[1,2-alpha]quinoline in two human colorectal cancer cell lines differing in p53 gene status. We used a proteomic approach based on two-dimensional gel electrophoresis coupled with mass spectrometry to complement the results obtained by common molecular biology methods for analyzing cell proliferation,...

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