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Article

Chaperoning SNARE Folding and Assembly.

Annual review of biochemistry - 20 Jun 2021

Zhang Yongli, Hughson Frederick M

Abstract excerpt

SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to couple their folding and assembly to membrane fusion, the physiological pathways of SNARE assembly and the mechanistic roles of SM proteins have long been enigmatic. Here, we review recent advances in understanding the SNARE-SM fusion...

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Identifiers

PMID: 33823650
DOI: 10.1146/annurev-biochem-081820-103615
PMCID: PMC8900292

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