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Article

Effect of variation in 5'-regulatory region of insulin receptor substrate-1 gene on gene expression.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 Dec 2006

Huang Jian-jun, Liu Hong-bo, Xu Xia, Song Hui-ping

Abstract excerpt

UNLABELLED: OBJECTIVE; To determine the effect of a variation of CAG-rich region, which was found in the 5'-regulatory sequence of insulin receptor substrate-1(IRS-1) gene in Type 2 diabetes mellitus(T2DM) patients, on gene expression and its mechanism. METHODS: The recombinants, pGL2.P-T3 and pGL2.P-T5, were constructed with luciferase reporter vector, pGL2 promoter. T3 and T5 were wild-type and variant alleles,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17213575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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