Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles.

Nature communications - 5 Jun 2020

Wang Daning, Liu Xinlin, Wei Minxi, Qian Ciying, Song Shuo, Chen Jie, Wang Zhiping, Xu Qin, Yang Yurou, He Maozhou, Chi Xin, Huang Shiwen, Li Tingting, Kong Zhibo, Zheng Qingbing, Yu Hai, Wang Yingbin, Zhao Qinjian, Zhang Jun, Xia Ningshao, Gu Ying, Li Shaowei

Abstract excerpt

The capsid of human papillomavirus (HPV) spontaneously arranges into a T = 7 icosahedral particle with 72 L1 pentameric capsomeres associating via disulfide bonds between Cys175 and Cys428. Here, we design a capsomere-hybrid virus-like particle (chVLP) to accommodate multiple types of L1 pentamers by the reciprocal assembly of single C175A and C428A L1 mutants, either of which alone encumbers L1 pentamer particle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsid Proteins

Share to Drug Design

Share to Immunogenicity, Vaccine

Share to Models, Animal

Share to Neutralization Tests

Share to Papillomavirus Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 32503989
DOI: 10.1038/s41467-020-16639-1
PMCID: PMC7275066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles.PMID 32503989Read ↗

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificitySemantic proximity Read ↗

N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitroSemantic proximity Read ↗

Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeresSemantic proximity Read ↗

Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and ImmunogenicitySemantic proximity Read ↗

Virus-like Particle-Based L2 Vaccines against HPVs: Where Are We Today?Semantic proximity Read ↗

Hybrid Papillomavirus L1 Molecules Assemble into Virus-like Particles That Reconstitute Conformational Epitopes and Induce Neutralizing Antibodies to Distinct HPV TypesSemantic proximity Read ↗

Progress in L2-Based Prophylactic Vaccine Development for Protection against Diverse Human Papillomavirus Genotypes and Associated DiseasesSemantic proximity Read ↗

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine CandidatesSemantic proximity Read ↗

Rational Design of Peptide Vaccines against Multiple Types of Human PapillomavirusSemantic proximity Read ↗

Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody.Semantic proximity Read ↗

Amino acid sequence diversity of the major human papillomavirus capsid protein: implications for current and next generation vaccines.Semantic proximity Read ↗

Multi-Strain Human Papillomavirus (HPV) Vaccine Innovation via Computational Study: A Mini ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.