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Article

TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis.

International journal of immunopathology and pharmacology - 1 Jan 2000

Sainz J, Salas-Alvarado I, López-Fernández E, Olmedo C, Comino A, García F, Blanco A, Gómez-Lopera S, Oyonarte S, Bueno P, Jurado M

Abstract excerpt

Tumour necrosis factor (TNF) is primarily secreted by monocytes/macrophages and activated T lymphocytes in response to fungal infections. TNF acts through TNF receptor 1 (TNFR1) triggering a pro-inflammatory response, and therefore plays a pivotal role in immune regulation and host immune responses. We hypothesized that single nucleotide polymorphisms (SNPs) in TNFR1 gene may influence the innate immune response...

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PMID: 20646338
DOI: 10.1177/039463201002300205

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TNF

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