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Article

At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction.

PloS one - 3 Jan 2007

Glisic-Milosavljevic Sanja, Waukau Jill, Jailwala Parthav, Jana Srikanta, Khoo Huoy-Jii, Albertz Hope, Woodliff Jeffrey, Koppen Marilyn, Alemzadeh Ramin, Hagopian William, Ghosh Soumitra

Abstract excerpt

BACKGROUND: In experimental models, Type 1 diabetes T1D can be prevented by adoptive transfer of CD4+CD25+ (FoxP3+) suppressor or regulatory T cells. Recent studies have found a suppression defect of CD4+CD25+(high) T cells in human disease. In this study we measure apoptosis of CD4+CD25+(high) T cells to see if it could contribute to reduced suppressive activity of these cells. METHODS AND FINDINGS: T-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17206281
DOI: 10.1371/journal.pone.0000146
PMCID: PMC1764033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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