Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1.

doi:10.1073/pnas.88.23.10971

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Article

Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1991

Terwilliger E F, Langhoff E, Gabuzda D, Zazopoulos E, Haseltine W A

Abstract excerpt

The effects of the viral gene nef on human immunodeficiency virus type 1 (HIV-1) replication in culture were investigated using nef alleles of the HIV-1 IIIB and ELI strains. The results demonstrate significant allelic variation in the effect of nef on virus replication in both an established human CD4+ T-cell line and primary human lymphocytes. In the context of the HXB2 virus, the ELI nef allele but not the...

Topics

Alleles
Cell Line
Cells, Cultured
Genes, nef
Genetic Variation
HIV-1
Humans
Kinetics
Lymphocyte Activation
Macrophages
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proviruses

RNA-Directed DNA Polymerase

Restriction Mapping

T-Lymphocytes

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1720558
DOI: 10.1073/pnas.88.23.10971
PMCID: PMC53054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1720558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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