Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains.

The Journal of biological chemistry - 2 Mar 2007

Lu Hong, Wu Jeng Yih, Beswick Ellen J, Ohno Tomoyuki, Odenbreit Stefan, Haas Rainer, Reyes Victor E, Kita Masakazu, Graham David Y, Yamaoka Yoshio

Abstract excerpt

Following adhesion of Helicobacter pylori to gastric epithelial cells, intracellular signaling leads to cytokine production, which causes H. pylori-related gastric injury. Two adjacent homologous genes (alpA and alpB), which encode H. pylori outer membrane proteins, are thought to be associated with adhesion and cytokine induction. We co-cultured gastric epithelial cells with wild type H. pylori strains and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adhesins, Bacterial
Share to Bacterial Outer Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Epithelial Cells

Share to Geography

Share to Helicobacter pylori

Share to Inflammation

Share to Stomach

Source

Open in PubMed Open full text

Identifiers

PMID: 17202133
DOI: 10.1074/jbc.M611178200
PMCID: PMC3130062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains.PMID 17202133Read ↗

Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue.Semantic proximity Read ↗

Role of the AlpAB proteins and lipopolysaccharide in adhesion of Helicobacter pylori to human gastric tissueSemantic proximity Read ↗

Helicobacter pylori AlpA and AlpB Bind Host Laminin and Influence Gastric Inflammation in GerbilsSemantic proximity Read ↗

Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells.Semantic proximity Read ↗

Diversification of the AlpB Outer Membrane Protein of Helicobacter pylori Affects Biofilm Formation and Cellular Adhesion.Semantic proximity Read ↗

Increasing evidence of the role of Helicobacter pylori SabA in the pathogenesis of gastroduodenal diseaseSemantic proximity Read ↗

HpaA shows variable surface localization but the gene expression is similar in different Helicobacter pylori strainsSemantic proximity Read ↗

The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response.Semantic proximity Read ↗

Lactate causes downregulation of Helicobacter pylori adhesin genes sabA and labA while dampening the production of proinflammatory cytokinesSemantic proximity Read ↗

Activation of IL-8 Gene Expression by <i>Helicobacter pylori</i> Is Regulated by Transcription Factor Nuclear Factor-κB in Gastric Epithelial CellsSemantic proximity Read ↗

Helicobacter pylori infection in mice: Role of outer membrane proteins in colonization and inflammation.Semantic proximity Read ↗

IV.Helicobacter pyloristrain-specific activation of signal transduction cascades related to gastric inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.