Article
Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer.
Journal of gastroenterology and hepatology - 1 Jan 2007
Sugimoto Mitsushige, Furuta Takahisa, Shirai Naohito, Nakamura Akiko, Xiao Fang, Kajimura Masayoshi, Sugimura Haruhiko, Hishida Akira
Abstract excerpt
BACKGROUND AND AIM: In Western countries, polymorphism of pro-inflammatory cytokine genes is associated with the development of gastric cancer and duodenal ulcer. The aim of this study was to clarify the association of polymorphisms of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha with susceptibility to peptic ulcer diseases and gastric cancer in Japan. METHODS: The IL-1beta-511/-31 and...
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