Article
Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Apr 2002
Morelli V M, Lourenço D M, D'Almeida V, Franco R F, Miranda F, Zago M A, Noguti M A E, Cruz E, Kerbauy J
Abstract excerpt
Fasting total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation were evaluated in 91 patients with venous thromboembolism and without acquired thrombophilia, and in 91 age-matched and sex-matched controls. Hyperhomocysteinemia was detected in 11 patients (12.1%) and in two controls (2.2%), yielding an odds ratio (OR) for venous thrombosis of 6.1 [95% confidence interval (CI),...
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