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Article

Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.

Biochemistry - 9 Jan 2007

Manieri Wanda, Moore Molly E, Soellner Matthew B, Tsang Pearl, Caperelli Carol A

Abstract excerpt

Human glycinamide ribonucleotide transformylase (GART) (EC 2.1.2.2) is a validated target for cancer chemotherapy, but mechanistic studies of this therapeutically important enzyme are limited. Site-directed mutagenesis, initial velocity studies, pH-rate studies, and substrate binding studies have been employed to probe the role of the strictly conserved active site residues, N106, H108, and D144, and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17198385
DOI: 10.1021/bi0619270
PMCID: PMC2518408

Genes

GART

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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