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Article

The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.

Biochimica et biophysica acta - 1 Mar 2007

Dorfmeister Birgit, Cooper Jackie A, Stephens Jeffrey W, Ireland Helen, Hurel Steven J, Humphries Steve E, Talmud Philippa J

Abstract excerpt

Common variants in APOA5 and APOC3 have been associated with differences in plasma triglyceride (TG) levels in healthy individuals. The aim of this study was to examine the association of APOA5 (-1131T>C, S19W) and APOC3 (-482C>T, 1100C>T) polymorphisms in patients with type 2 diabetes (T2D) of European White (EW) (n=931), Indian Asian (IA) (n=610) and Afro-Caribbean (AC) (n=167) origin, with lipid and T2D...

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Source

Identifiers

PMID: 17197160
DOI: 10.1016/j.bbadis.2006.11.008

Genes

APOC3
APOA5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.PMID 17197160Read ↗

-1131T>C and SW19 polymorphisms in APOA5 gene and lipid levels in type 2 diabetic patients.Semantic proximity Read ↗

Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients.Semantic proximity Read ↗

Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges.Semantic proximity Read ↗

Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans.Semantic proximity Read ↗

Contribution of APOA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women.Semantic proximity Read ↗

Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.Semantic proximity Read ↗

Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups.Semantic proximity Read ↗

The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study.Semantic proximity Read ↗

APOA5 variants and metabolic syndrome in Caucasians.Semantic proximity Read ↗

Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes.Semantic proximity Read ↗

APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population.Semantic proximity Read ↗

Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome.Semantic proximity Read ↗

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