Article
Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population.
Arthritis and rheumatism - 1 Jan 2007
Takata Yoichiro, Hamada Daisuke, Miyatake Katsutoshi, Nakano Shunji, Shinomiya Fumio, Scafe Charles R, Reeve Vincent M, Osabe Dai, Moritani Maki, Kunika Kiyoshi, Kamatani Naoyuki, Inoue Hiroshi, Yasui Natsuo, Itakura Mitsuo
Abstract excerpt
OBJECTIVE: Analyses of families with rheumatoid arthritis (RA) have suggested the presence of a putative susceptibility locus on chromosome 14q21-23. This large population-based genetic association study was undertaken to examine this region. METHODS: A 2-stage case-control association study of 950 unrelated Japanese patients with RA and 950 healthy controls was performed using >400 gene-based common...
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