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Article

A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.

Nature genetics - 1 Feb 2007

Kubo Michiaki, Hata Jun, Ninomiya Toshiharu, Matsuda Koichi, Yonemoto Koji, Nakano Toshiaki, Matsushita Tomonaga, Yamazaki Keiko, Ohnishi Yozo, Saito Susumu, Kitazono Takanari, Ibayashi Setsuro, Sueishi Katsuo, Iida Mitsuo, Nakamura Yusuke, Kiyohara Yutaka

Abstract excerpt

Cerebral infarction is the most common type of stroke and often causes long-term disability. To investigate the genetic contribution to cerebral infarction, we conducted a case-control study using 52,608 gene-based tag SNPs selected from the JSNP database. Here we report that a nonsynonymous SNP in a member of protein kinase C (PKC) family, PRKCH, was significantly associated with lacunar infarction in two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17206144
DOI: 10.1038/ng1945

Genes

PRKCH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.PMID 17206144Read ↗

[Genetic risk factors of ischemic stroke identified by a genome-wide association study].Semantic proximity Read ↗

[Genome-wide association study for ischemic stroke based on the Hisayama study].Semantic proximity Read ↗

[Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)].Semantic proximity Read ↗

Association between PRKCH gene polymorphisms and subcortical silent brain infarction.Semantic proximity Read ↗

The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population.Semantic proximity Read ↗

Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls.Semantic proximity Read ↗

Association of PRKCH gene with lacunar infarction in a local Chinese Han population.Semantic proximity Read ↗

Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population.Semantic proximity Read ↗

Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population.Semantic proximity Read ↗

The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population.Semantic proximity Read ↗

Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population.Semantic proximity Read ↗

PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population.Semantic proximity Read ↗

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