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Article

Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.

Human gene therapy - 20 Jan 2000

Motoi F, Sunamura M, Ding L, Duda D G, Yoshida Y, Zhang W, Matsuno S, Hamada H

Abstract excerpt

Pancreatic cancer has a poor prognosis even when surgical treatment can be accomplished. Studies have demonstrated that pancreatic cancer is associated with various genetic abnormalities in oncogenes and tumor suppressor genes including p53. New therapeutic approaches for pancreatic cancer can be developed by targeting these genetic alterations. Adenovirus (Adv) lacking the 55-kDa E1B protein (E1B55K) replicates...

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PMID: 10680837
DOI: 10.1089/10430340050015978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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