Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.

FEMS microbiology letters - 1 Mar 2007

Capone Ricardo F, Ning Yu, Pakulis Nora, Alhazzazi Turki, Fenno J Christopher

Abstract excerpt

The Treponema denticola ATCC 35405 genome annotation contains most of the genes for de novo pyrimidine biosynthesis. To initiate characterization of pyrimidine synthesis in Treponema, we focused on TDE2110 (the putative pyrF, encoding orotidine-5'-monophosphate decarboxlyase). Unlike the parent strain, an isogenic pyrF mutant was resistant to 5-fluoroorotic acid. In complex medium, growth of the pyrF mutant was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Culture Media
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Orotic Acid

Share to Orotidine-5'-Phosphate Decarboxylase

Share to Pyrimidines

Share to Uracil

Source

Identifiers

PMID: 17187656
DOI: 10.1111/j.1574-6968.2006.00589.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.PMID 17187656Read ↗

Cloning and characterization of ftsZ and pyrF from the archaeon Thermoplasma acidophilum.Semantic proximity Read ↗

Pyrimidine biosynthesis genes (pyrE and pyrF) of an extreme thermophile, Thermus thermophilus.Semantic proximity Read ↗

Positive selection for Dictyostelium discoideum mutants lacking UMP synthase activity based on resistance to 5-fluoroorotic acid.Semantic proximity Read ↗

A mutation in the putative CRP binding site of the dctA promoter of Salmonella enterica serovar Typhimurium enables growth with low orotate concentrations.Semantic proximity Read ↗

The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.Semantic proximity Read ↗

PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.Semantic proximity Read ↗

Pyrimidine biosynthetic pathway of Pseudomonas fluorescens.Semantic proximity Read ↗

Sulfolobus acidocaldarius synthesizes UMP via a standard de novo pathway: results of biochemical-genetic study.Semantic proximity Read ↗

Interallelic complementation at the pyrF locus and the homodimeric nature of orotate phosphoribosyltransferase (OPRTase) in Mucor circinelloides.Semantic proximity Read ↗

The transcription of the gene for iso-orotate decarboxylase (IDCase), an enzyme of the thymidine salvage pathway, is downregulated in the pregc mutant strain of Neurospora crassa grown under phosphate starvation.Semantic proximity Read ↗

Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.Semantic proximity Read ↗

Molecular cloning of the pyrE gene from the extreme thermophile Thermus flavus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.