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Article

PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.

Science China. Life sciences - 1 May 2013

Sun Xianyun, Zhu Jufen, Bao Li, Hu Chengcheng, Jin Cheng, Harris Steven D, Liu Hongwei, Li Shaojie

Abstract excerpt

Tight control of the intracellular uracil level is believed to be important to reduce the occurrence of uracil incorporation into DNA. The pyrG gene of Aspergillus nidulans encodes orotidine 5'-phosphate decarboxylase, which catalyzes the conversion of orotidine monophosphate (OMP) to uridine monophosphate (UMP). In this study, we found that pyrG is critical for maintaining uracil at a low concentration in A....

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PMID: 23633078
DOI: 10.1007/s11427-013-4480-6

Genes

OMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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