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Article

Detecting mutations that confer oxazolidinone resistance in gram-positive bacteria.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007

Woodford Neil, North Sarah E, Ellington Matthew J

Abstract excerpt

Resistance to oxazolidinone antibiotics, including linezolid, in Gram-positive bacteria is mediated by single-nucleotide polymorphisms (SNPs) in the 23S ribosomal RNA. A G2576U change (encoded by a G2576T mutation in the rRNA genes) is found in most resistant clinical isolates of enterococci and staphylococci; a variety of changes have been found in resistant mutants selected in vitro. Pyrosequencing can be used...

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Source

Identifiers

PMID: 17185761
DOI: 10.1385/1-59745-377-3:103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detecting mutations that confer oxazolidinone resistance in gram-positive bacteria.PMID 17185761Read ↗

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Mechanisms of Linezolid Resistance among Coagulase-Negative Staphylococci Determined by Whole-Genome SequencingSemantic proximity Read ↗

Genetic methods for assessing antimicrobial resistance.Semantic proximity Read ↗

Comprehensive antibiotic-linked mutation assessment by Resistance Mutation Sequencing (RM-seq)Semantic proximity Read ↗

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Is it possible to identify genotypes underlying resistant phenotypes in Gram-negative pathogens?Semantic proximity Read ↗

Oxazolidinones: mechanisms of resistance and mobile genetic elements involvedSemantic proximity Read ↗

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