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Is it possible to identify genotypes underlying resistant phenotypes in Gram-negative pathogens?

Current opinion in infectious diseases - 1 Dec 2025

Burillo Almudena, Serrano-Lobo Julia, Bouza Emilio, Muñoz Patricia

Abstract excerpt

PURPOSE OF REVIEW: This review explores the relationship between genotypes and resistant phenotypes in Gram-negative pathogens. We analyse to what extent conventional phenotypic methods predict genetic mechanisms of resistance, the reliability of genotypic approaches, and how integrated strategies may improve diagnostic accuracy and clinical utility. RECENT FINDINGS: Traditional AST remains the clinical reference...

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PMID: 41151605
DOI: 10.1097/QCO.0000000000001158

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