Article
The Candida albicans AAA ATPase homologue of Saccharomyces cerevisiae Rix7p (YLL034c) is essential for proper morphology, biofilm formation and activity of secreted aspartyl proteinases.
Genetics and molecular research : GMR - 30 Nov 2006
Melo A S A, Padovan A C B, Serafim R C, Puzer L, Carmona A K, Juliano Neto L, Brunstein A, Briones M R S
Abstract excerpt
Proper morphology is essential for the ability of Candida albicans to switch between yeast and hyphae and thereby sustain its virulence. Here we identified, by differential screening, a novel C. albicans AAA ATPase encoding gene, CaYLL34 (RIX7), with enhanced expression in hyphae. Phylogenetic analysis suggests that CaYLL34 belongs to a "VCP-like" subgroup of AAA ATPases essential for yeast viability and contains...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.