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Article

Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway.

Journal of the American Society of Nephrology : JASN - 1 Jan 2007

He John Cijiang, Lu Ting-Chi, Fleet Margaret, Sunamoto Masaaki, Husain Mohammad, Fang Wei, Neves Susana, Chen Yibang, Shankland Stuart, Iyengar Ravi, Klotman Paul E

Abstract excerpt

HIV-associated nephropathy is characterized by renal podocyte proliferation and dedifferentiation. This study found that all-trans retinoic acid (atRA) reverses the effects of HIV-1 infection in podocytes. Treatment with atRA reduced cell proliferation rate by causing G1 arrest and restored the expression of the differentiation markers (synaptopodin, nephrin, podocin, and WT-1) in HIV-1-infected podocytes. It is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17182884
DOI: 10.1681/ASN.2006070727
PMCID: PMC3197239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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