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Article

N-WASP Involvement in Dorsal Ruffle Formation in Mouse Embryonic Fibroblasts

21 Dec 2006

Abstract excerpt

The Wiskott-Aldrich syndrome protein (WASP) family activates the Arp2/3 complex leading to the formation of new actin filaments. Here, we study the involvement of Scar1, Scar2, N-WASP, and Arp2/3 complex in dorsal ruffle formation in mouse embryonic fibroblasts (MEFs). Using platelet-derived growth factor to stimulate circular dorsal ruffle assembly in primary E13 and immortalized E9 Scar1(+/+) and Scar1 null...

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PMID: 17182853
DOI: 10.1091/mbc.e06-06-0569

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