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Article

Effects of budesonide on P‐glycoprotein expression in intestinal cell lines

18 Dec 2006

Abstract excerpt

BACKGROUND AND PURPOSE: P-glycoprotein (P-gp) is an important efflux transporter that supports the barrier function of the gut against invading antigens and against administered drugs. Since glucocorticoids, such as budesonide, are frequently used during inflammatory bowel disease we investigated how budesonide influences P-gp expression in different intestinal cell lines. EXPERIMENTAL APPROACH: LS180 and Caco-2...

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PMID: 17179942
DOI: 10.1038/sj.bjp.0706992

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