Article
Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2006
Dilger Karin, Cascorbi Ingolf, Grünhage Frank, Hohenester Simon, Sauerbruch Tilman, Beuers Ulrich
Abstract excerpt
BACKGROUND: Budesonide, which is a dual substrate of P-glycoprotein, the product of the multidrug resistance 1 (MDR1) gene, and cytochrome P450 3A (CYP3A) has been proposed for treatment of early primary biliary cirrhosis (PBC). Recently, MDR1 gene polymorphisms have been discussed as a potential cause of glucocorticoid resistance. We tested the hypothesis that MDR1 gene polymorphisms affect absorption of oral...
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