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Article

Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function.

Autoimmunity - 1 Dec 2006

Kyttaris Vasileios C, Krishnan Sandeep, Tsokos George C

Abstract excerpt

Overactive B cells, abnormally activated T cells and inappropriate handling of cellular debris by the innate immune system are central in the pathogenesis of systemic lupus erythematosus (SLE). Genetic studies in SLE patients have unraveled allelic variations in genes encoding key molecules that control inter- and intra-cellular signaling and play a role in the abnormal handling of apoptotic material. Despite...

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Identifiers

PMID: 17178567
DOI: 10.1080/08916930601061363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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