Article
Leukotriene B4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction.
Clinical science (London, England : 1979) - 1 Jun 2007
Maznyczka Annette, Mangino Massimo, Whittaker Andrew, Braund Peter, Palmer Tom, Tobin Martin, Goodall Alison H, Bradding Peter, Samani Nilesh J
Abstract excerpt
Leukotrienes are implicated in the pathogenesis of coronary artery disease. Recently two haplotypes (HapA and HapB) in the gene encoding ALOX5AP (arachidonate 5-lipoxygenase-activating protein), the main regulator of 5-lipoxygenase, have been associated with a doubling of the risk of myocardial infarction. Studies have also shown that treatment with a leukotriene inhibitor reduces biomarkers of coronary risk in...
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