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Article

Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.

Nature genetics - 1 Apr 2004

Knight Julian C, Keating Brendan J, Kwiatkowski Dominic P

Abstract excerpt

Genetic variation at the human LTA locus, encoding lymphotoxin-alpha, is associated with susceptibility to myocardial infarction, asthma and other diseases. By detailed haplotypic analysis of the locus, we identified a single-nucleotide polymorphism (SNP) at LTA+80 as a main predictor of LTA protein production by human B cells. We found that activated B-cell factor-1 (ABF-1) binds to this site in vitro and...

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Alleles
Cell Line, Transformed
Electrophoretic Mobility Shift Assay
Gene Expression Regulation
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphotoxin-alpha

Precipitin Tests

Source

Identifiers

PMID: 15052269
DOI: 10.1038/ng1331

Genes

LTA

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